Mikhail V. Dubovichenko

Часть публикаций из профиля, по году от новых к старым. Это не полный список последних работ автора; работы без года — в конце.

• The efficacy of oligonucleotide-based gene therapeutics in gene silencing2025
• Multivalent DNAzyme agents for cleaving folded RNA2024 · аннотациясвернуть

  Multivalent recognition and binding of biological molecules is a natural phenomenon that increases the binding stability (avidity) without decreasing the recognition specificity. In this study, we took advantage of this…

• Cleaving Folded RNA by Multifunctional DNAzyme Nanomachines2024
• Marker‐Dependent Cleavage of RNA by Binary (split) DNAzyme (BiDz) and Binary DNA Machines (BiDM)2024
• Comparison of Antisense Oligonucleotides, DNAzymes, and Their Bivalent Forms in RNAse H Dependent Cleavage of Folded RNA2024
• BIVALENT ANTISENSE OLIGONUCLEOTIDES FOR INCREASED SELECTIVITY AND EFFICIENCY OF RNA DEGRADATION2024
• Cleaving Folded RNA with DNAzyme Agents2023 · аннотациясвернуть

  Abstract Cleavage of biological mRNA by DNAzymes (Dz) has been proposed as a variation of oligonucleotide gene therapy (OGT). The design of Dz‐based OGT agents includes computational prediction of two RNA‐binding arms…

• Specificity of oligonucleotide gene therapy (OGT) agents2022 · аннотациясвернуть

  Oligonucleotide gene therapy (OGT) agents (e. g. antisense, deoxyribozymes, siRNA and CRISPR/Cas) are promising therapeutic tools.Despite extensive efforts, only few OGT drugs have been approved for clinical use.Besides…