Nadezhda S. Dyrkheeva

Часть публикаций из профиля, по году от новых к старым. Это не полный список последних работ автора; работы без года — в конце.

• Safety and Antitumor Activity of the Usnic Acid Derivative OL9‑116, a TDP1 Inhibitor, as an Adjunctive Therapy in Combination with Topotecan2026
• The Influence of TDP1 Inhibitor Usnic Acid Derivative OL9-116 on the Effects of Topotecan in Human Cells2026
• Special Issue “New Agents and Novel Drugs Use for the Oncological Diseases Treatment”2026
• [Amidothiazole Derivatives of (+)-Usnic Acid Effectively Inhibit TDP1 and Sensitize Tumor Cells to the Effects of Topotecan].2025
• The effect of dimeric bisbenzimidazoles on the activity of DNA repair enzymes TDP1, TDP2, PARP1 and PARP22025
• New Hydrazinothiazole Derivatives of Usnic Acid as Potent Tdp1 Inhibitors2019 · аннотациясвернуть

  Tyrosyl-DNA phosphodiesterase 1 (Tdp1) is a promising therapeutic target in cancer therapy. Combination chemotherapy using Tdp1 inhibitors as a component can potentially improve therapeutic response to many…

• Dual DNA topoisomerase 1 and tyrosyl‐DNA phosphodiesterase 1 inhibition for improved anticancer activity2019
• Tyrosyl-DNA Phosphodiesterase 1 Inhibitors: Usnic Acid Enamines Enhance the Cytotoxic Effect of Camptothecin2016 · аннотациясвернуть

  Tyrosyl-DNA phosphodiesterase 1 (TDP1) is a repair enzyme for stalled DNA-topoisomerase 1 (Top1) cleavage complexes and other 3′-end DNA lesions. TDP1 is a perspective target for anticancer therapy based on…